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艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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DRG International.jpg

DRG是一家专业医疗诊断试剂、设备的制造商和经销商,并在100多个国家有分支机构和合作伙伴。DRG®公司重点发展高科技精准医疗诊断产品,涉及领域有:肿瘤、妇科、内分泌科、糖尿病、自体免疫、传染病和毒理学等。DRG®还拥有高水准的专业医疗、临床、营销策划和服务方面的专家,通过与分布在世界各地的分公司及代理商的合作,DRG®公司为全世界的客户提供全方位质优创新的临床检验产品和服务。

 

DRG International, Inc. is a leading specialty medical diagnostics and equipment manufacturer, and distributor with operations in more than 110 countries. Founded in 1970, DRG International provides a complete range of products and services to the diagnostics and cardiology-related medical community. DRG International’s global headquarters is conveniently situated in Springfield, New Jersey, accessible from State Route 22 and minutes away from route I-78 and the Garden State Parkway. Only 20 miles from New York City and 80 miles from Philadelphia, PA, DRG International, Inc. is in the heart of the beautiful Tri-State Area.

 

DRG international公司的主要产品包括:

Chemiluminescence Immunoassays (CLAS)

Diabetes / Gastrointestinal and Pankreatic

Drug Monitoring

Endocrinology

Fertility and Pregnancy

Pituitary / Adrenal Function

Immunology / Hematology

Cardiovascular Diseases

Bone and Mineral Metabolism

Leukotrienes and Prostaglandins

Neuropeptides

Thyroid Function

Saliva Diagnostics

Tumor Diagnosis

Infectious Diseases

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全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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艾美捷科技代理Lifeome品牌全系列产品


Lifeome公司致力于基因组学、转录组学及蛋白质组学领域的产品研发、生产与市场化,提供全方位的研究产品与服务体系。Lifeome核心产品包括生长因子、抗体、病毒蛋白、重组蛋白,基因工程克隆载体等。


▍Lifeome公司的服务

● 定制抗体开发服务:多克隆与单克隆抗体解决方案,应用于蛋白定量检测、细胞/组织定位分析(活体或固定样本),由政府认证实验室提供全流程生产服务;

● 高端多肽合成解决方案:由平均从业5年以上的技术专家操作顶级合成系统,覆盖从基础科研到工业级生产需求;

● 蛋白质表达与纯化:其培养简便、产量高,能快速获得免疫原。


Lifeome.png


Cytokines
Bone Morphogenetic ProteinBeta DefensinEndoglinInterleukinSerum Amyloid A
Leukemia Inhibitory FactorBetacellulinFlt3 LigandApoliproteinsThrombopoietin
B Cell Activating FactorAngiopoietinHedgehog ProgeinOthersTrefoil Factor
B type Natriuretic PeptideEBI3InterferonResistinVisfatin
Tumor Necrosis Factor



Chemokines
ENA 78IL-8 (CXCL8)MDC (CCL22)NAP-2 (CXCL7)SDF (CXCL12)
Lymphotactin (XCL1)IP-10 (CXCL10)MEC (CCL28)OthersTARC (CCL17)
Platelet Factor-4 (CXCL4)EotaxinMIG (CXCL9)GRORantes (CCL5)
I-TAC (CXCL11)MCPMIP

Recombinant Proteins
ADP-Ribosylation FactorCardiac TroponinSuperoxide DismutaseProfilinStreptavidin
Synaptosomal Associated ProteinChromograninHypoxia-Inducible FactorBIDHSP
TNF receptor-Associated FactorcJunU6 Small Nuclear RNAProtein-A, A/G & GSynaptobrevin
Microtubule-Associated ProteinAnnexinMelanoma AntigenRAS OncogeneAlbumin
Myelin Oligodendrocyte GlycoPAprotininCoaggulation FactorsCalbindinSyndecan
Translation Initiation FactorsCollagenCoagulation FactorsCell Division CycleSynuclein
B Cell LymphomaCrystallinMyoglobinCentromere ProteinThioredoxin
Beta 2 MicroglobulinCystatinMyosin Light ChainRibosomal ProteinThrombin
Programmed Cell DeathCytokeratinDNA-Damage ProteinSecretagoginAllergy
C-Reactive ProteinNanogNatural ProteinsSelectinTransferrin
Ras-Related C3 Botulinum Tox...Dynein Light ChainNon-Metastatic CellsSeptinTransgelin
Calcium Binding ProteinEphrinVisinin-Like ProteinSerpinAvidin
Small Nuclear Ribonucleo...ER ProteinsOuter Membrane ProteinCD AntigensTropomyosin
Chloride Intracellular ChannelFABPp53SirtuinTrypsin
Sex Determining Region Y BoxFerritinPCNASMADKiller Cell
Regenerating Islet-DerivedFibronectinPOU ClassCalmodulinUbiquitin
Regulator of G-Protein SignalingPrefoldinHigh-Mobility GroupStathminVimentin
Antibodies
Anti Human ChemokineAnti ViralAnti Human CytokineAnti Human EnzymesAnti Human HSP
Anti Human LymphocyteELISA PairsAnti Mouse LymphocyteAnti Expression TagsAnti Mouse Cytokine
Polyclonal Rabbit AntibodiesRare Antibodies


Viral Proteins
BorreliaEBVHepatitis CMalariaRubella
ChagasEncephalitisHepatitis DMeaslesS. Typhi
ChikungunyaWest NileHepatitis EMumpsSARS
ChlamydiaHantavirusHerpesMycoplasmaShiga Like Toxin
CytomegaloHBsAgHIVNorovirusToxoplasma
DengueHepatitis AHTLVPapillomavirusTreponema
EbolaHepatitis BInfluenzaParvovirusVaricella
Feline Leukemia VirusZika


Growth Factors
Melanoma Inhibitory ProteinsGalectinKeratinocyte GFOmentinProlactin
Colony Stimulating FactorGrowth HormoneLeptinOncostatin-MRANK Ligand
Hepatocyte Growth FactorCTGFMacrophage Migration IFOsteoprotegerinRetinol Binding P
Epidermal Growth FactorIGFBPActivinOthersStem Cell Factor
Transforming Growth FactorInsulinMyostatinPDGFErythropoietin
Fibroblast Growth FactorInsulin-like GFNogginPlacental LactogenVEGF
Research Reagents
Biochemical KitsCoVID19CRISPR-Cas9Media/PlatesMolecular Markers
Nucleic Acids PurificationSeamless Cloning


Primary Cells
DogGoatMouseRabbitRat
ELISA
ChemiluminescentHRPSpecialty Kits
Xpress Clones-cis Element Reporter
Bacterial ClonesMammalian Clones-Hygromycin KitsNeomycin Kits


▍Lifeome部分产品列表

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品名货号规格
Primary AC Cell, DogCSI003Ca01-500k5x10^5
Primary AEC Cell, DogCSI006Ca01-500k5x10^5
Primary AFC Cell, DogCSI008Ca01-500k5x10^5
Primary ASMC Cell, DogCSI153Ca01-500k5x10^5
Primary BMMC Cell, DogCSI164Ca01-500k5x10^5
Primary BMMSCs Cell, DogCSI083Ca01-500k5x10^5
Primary MC Cell, DogCSI007Ca01-500k5x10^5
Primary NDF Cell, DogCSI088Ca01-500k5x10^5
Primary NPC Cell, DogCSI113Ca01-500k5x10^5
Primary OB Cell, DogCSI102Ca01-500k5x10^5
Primary OF Cell, DogCSI138Ca01-500k5x10^5
Primary RCEC Cell, DogCSI067Ca01-500k5x10^5
Primary SEC Cell, DogCSI112Ca01-500k5x10^5
Primary TDSC Cell, DogCSI255Ca01-500k5x10^5
Primary TSMC Cell, DogCSI068Ca01-500k5x10^5
Primary AC Cell, GoatCSI003Cp01-500k5x10^5
Primary ASMC Cell, GoatCSI153Cp01-500k5x10^5
Anti-APOB100 AntibodyA90603Hu01-1100 ug
Anti-APOC2 AntibodyPAB77963-1100 ug
Anti-HPR AntibodyA92000Hu01-1100 ug
Antibody to Mouse Insulin (INS)A90448Mu01-100ug100 ug
Antibody to Mouse Insulin (INS)A90448Mu01-50ug50 ug



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